Patient Information

CYMBALTA (Duloxetine)


General Guidelines:

Cymbalta is one of the few drugs to treat neuropathic pain that is unlikely to lead to overweight

Adequate trial at a given dose might take 4-6 weeks

Pain relief usually occurs before antidepressants effects, i.e., less than one week


Minimize side effects:

  • Start at lower dose, e.g., 30 mg / day Cymbalta and then increase the dose slowly. Cymbalta has been used up to 120 mg / day to treat chronic pain.
  • Take with food
  • Take at bedtime
  • Nausea is the most common side effect and is likely to disappear in 7-10 days
  • Consider combining treatment with Cymbalta with another class of drug used to treat neuropathic pain (e.g. Lyrica)



Dosage Schedule

Maximum Total Daily


60 mg QD (Click here for details) 60 mg



Side effects of CYMBALTA:

  • Nausea
  • Dry mouth
  • Constipation
  • Loss of appetite
  • Tiredness
  • Drowsiness
  • Dizziness
  • Increased sweating
  • Blurred vision
  • Yawning


Patient exclusion criteria:

  • Epileptic Seizure
  • Closed Angle Glaucoma
  • High Blood Pressure
  • Blood Pressure Drop Upon Standing
  • Hardening of the Liver caused by Alcohol
  • Chronic Inflammation of the Liver
  • Hardening of the Liver
  • Liver Problems
  • Serious Kidney Problems
  • Manic-Depression,
  • Having Thoughts of Suicide
  • Habit of Drinking Too Much Alcohol




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